Proteomics, Inflammatory Response, Mass Spectrometry

PRISM | U 1192
Biology and health Research unit Precision health

PRISM laboratory is a unique laboratory creating and developing new diagnostic tools, treatments, technologies and fundamental biological concepts, all oriented towards personalized medicine in oncology and neurology. We utilize state-of-the art molecular imaging and multi-OMICs technologies to better understand the pathophysiology of oncological and neurological disorders as well as to discover new treatment options. Our research activity is structured around two main axes: technological innovations and therapeutic innovations. We also developed  two technological platforms: CLIC-Imaging, offering services in OMICS and mass spectrometry imaging; and 3D Cell OMICs, proposing services related to 3D cell culture (such as creation and maintenance of organoids and mixed spheroids, 3D organ bioprinting, exosome studies) for drug efficacy tests and for the development of new therapeutics. We are open to all academic and industrial collaborations and propose services in line with our expertise.

Informations

Director: Michel Salzet

https://laboratoire-prism.fr/

Bâtiment SN3, Avenue Paul Langevin
Campus Cité Scientifique, Université de Lille
59655 VILLENEUVE D’ASCQ

Mots-clés

Mass spectrometry, Proteomics, OMICS, Oncoimmunology, Oncology, Neurology, Exoxome, Translational

Localisation

  • Molecular imaging by mass spectrometry
  • SpiderMass in vivo mass spectrometry imaging
  • Proteomics
  • Lipidomics
  • Proteogenomics
  • Lipid imaging
  • Xenobiotic imaging
  • DMPK
  • ADME

Examples of projects:

  • SpiderMass : a novel instrument enabling non-targeted molecular information to be collected in-vivo for guided surgery. This system allows the minimally invasive collection of molecular data without requiring the use of probes or labeling.
  • MacBeth : development of a therapeutic strategy allowing the reactivation of macrophages present in tumors.
  • Ghost : development of mass spectrometry-based strategies to discover a new class of proteins “Alternative proteins” (altProts) or “Ghost Proteins”.
  • Molecular imaging by mass spectrometry (MALDI, DESI)
  • SpiderMass in vivo mass spectrometry imaging
  • Large scale non-targeted or targeted spatial proteomic analyzes
  • Preparation of samples from cells, tissues, organoids, spheroids, body fluids, extracellular vesicles and exosomes.
  • Identification of proteins or lipids
  • Multi-omics analyzes
  • Lipid imaging
  • Xenobiotic imaging
  • DMPK
  • ADME
  • Study of protein-protein interactions, post-translational modifications
  • Data processing and statistical analysis

We posess state-of-the-art tools for sample preparation, proteomic and mass spectrometric analysis and data analysis: 

  • MALDI-TOF imaging system
  • ESI-Q-Orbitrap mass spectrometer
  • Xevo G2-XS-Qtof mass spectrometer
  • EASY-nLC 1000 liquid chromatograph
  • 3D bioprinter BIO X
  • Sprayer HTX M5

See the detailed list of equipment.

Private
Oncovet Clinical Research (laboratoire commun O'DREAMS)

Academic
Imperial College of London ( European Associated Laboratory - LANCET), Université Stanford (USA), University of California San Diego (USA), University of Florida (USA), University of Negev, Ben-Gurion (Israel), Center of Excellence in Neuroimmunology (Slovakia), Laval University (Canada), Univ. Salento (Italy)...

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