Lille Platforms in Biology and Health
The seven platforms that make up PLBS provide access to the equipment and expertise needed to support research in biology and health. The technological, analytical and methodological approaches offered by PLBS range from the development of omics studies to cellular imaging, life imaging and functional exploration, as well as bioinformatics and biostatistics, high-throughput/high-content screening and experimental model housing facilities.
Primarily developed to meet the needs of academic research laboratories in life and health sciences at the University of Lille, PLBS is also open to national and international academic research activities as well as to industry.
Informations
Deputy director: Philippe Boutin
Director: Sophie Crespin
https://ums-plbs.univ-lille.fr/
https://twitter.com/UMS_PLBS?s=20
1 place de Verdun
Faculté de Médecine - Pôle Recherche, Université de Lille
59045 LILLE
Mots-clés
High content and high throughput screening, Cytometry, Light and electron microscopy, Bioinformatics, Genomics, Transcriptomics, PET and MRI imaging, Functional exploration, Glycoproteomics, Image and signal processingLocalisation
HIGH THROUGHPUT AND HIGH CONTENT SCREENING PLATFORM (ARIADNE CRIBLAGE):
- High content and high throughput screening
- Screening automation
- Automated confocal microscopy
- Target characterization and modulator optimization
BIOIMAGING CENTER LILLE (BICEL):
- Transmission electron imaging (TEM) and scanning (SEM)
- Photonic microscopy
- Conventional and spectral cytometry, flow imaging and cell sorting
- Sample preparation
- Intravital imaging
- Data analysis and interpretation
- Image analysis
LILLE BIOINFORMATICS PLATFORM (BILILLE):
- Development of analysis pipelines and databases
- Integrative biology
- Gene, genome and protein annotation
- Phylogeny
- Systems biology
- Structural bioinformatics
- Development of bioinformatics and biostatistics tools
GENOMICS PLATFORM (GO@L):
- "Whole genome" genomics
- Transcriptomics
- Metagenomics
- Whole genome sequencing and re-sequencing
- Re-sequencing of exomes of various qualities
- Targeted sequencing
- 16S targeted metagenomics
- RNA-seq and scRNA-seq
- DGE microarrays and DGE Nanostring
LIFE IMAGING (LIIFE):
- In vivo imaging acquisition in MRI and PET
- Translational research
- Multidisciplinary approaches (radiology, nuclear medicine, engineering)
- Functional and behavioral exploration
- Image processing and analysis
GLYCOMICS AND PROTEOMICS PLATFORM (PAGÉS/P3M):
- Composition and quantification of monosaccharides
- Study of complex mixture of glycans, poly- and oligosaccharides
- Structural glycobiology
- NMR spectroscopy (nuclear magnetic resonance)
- High throughput proteomics
- Study of post-translational modifications
- Glycoproteomics
- Native mass spectrometry
ANIMAL FACILITIES:
- Rodent and aquatic model housing
- Breeding of transgenic lines
- Functional and metabolic explorations
- Body composition analysis
Examples of projects:
For specialized services, see the profiles of our platforms:
- Genomics platform (GO@L)
- Glycomics and proteomics platform (PAGés-P3M)
- Lille Bioinformatics platform (bilille)
- Animal facilities (Experimental resources)
- Bioimaging center Lille (BICeL)
- Life imaging (LIIFE)
- High throughput and high content screening platform (Ariadne criblage)
Most of the PLBS equipment is made available to the community following practical training. Trainees can then use the equipment autonomously while benefiting from the assistance of engineers and technicians of the platforms. Specialized equipment that requires expert knowledge, or that is located in specific and/or particularly sensitive areas, can be accessed in collaborative mode or via a research or service agreements.
To see the detailed list of equipment, refer to the profiles of our platforms:
- Genomics platform (GO@L)
- Glycomics and proteomics platform (PAGés-P3M)
- Lille Bioinformatics platform (bilille)
- Animal facilities (Experimental resources)
- Bioimaging center Lille (BICeL)
- Life imaging (LIIFE)
- High throughput and high content screening platform (Ariadne criblage)
Private
Bioversys, Apteeus, GSK, Copalis, ANSES, OCR, Gènes Diffusion, Philips, General Electric, Siemens, Qynapse, Cleverdoc
Academic
Institute Pasteur Paris, Institute Necker Paris, Paris Orsay, University Paris Sud - Institute Galien, Paris Polytechnic Institute, Institute Curie, Institute Cochin, Technological University of Compiègne, University of Toulouse, Sorbonne University, University of Littoral Côte d'Opale, University of Rouen, University of Angers, Polytech Montpellier, University Hospital of Rouen, University Hospital of Nantes, University Hospital of Marseille, University Hospital of Amiens-Picardy, University Hospital of Bordeaux, Rothschild Foundation Hospital (Paris), UMR5240 - Microbiology, Adaptation and Pathogenesis, Platform "Exploration of Metabolism" INRA Clermont-Ferrand, U1086 ANTICIPE (Rouen), U1209 IAB (Grenoble), UMR7339 CRMBM (Marseille)
Université Libre de Bruxelles (Belgium), Sciensano (Belgium), Weizmann Institute for Science (Israel), Paul Langherans Institute Dresden (Germany), University hospital of Munich (Germany), Nagoya University (Japan), University of Sheffield (Great Britain), Massachusetts General Hospital (USA), University of Chicago (USA), University hospital of Maastricht (Netherlands)