Miniaturisation for Synthesis, Analysis and Proteomics

MSAP | USR 3290
Biology and health Chemistry and materials Research unit Precision health Science for a changing planet

MSAP is a service and research unit that is at the interface of chemistry and biology. We are well recognized internationally for our instrumental and analytical developments related to mass spectrometry and we have built a solid reputation in the field of art analysis or identification of biological macromolecules. In chemistry, the originality of our unit is based on flow synthesis (from milli- to nano-fluidic) with developments in photochemistry or nanoparticle synthesis. MSAP also includes a mass spectrometry platform as well as a proteomics platform, and benefits from access to state-of-the-art equipment. We are open to all academic and industrial collaborations and propose services in line with our expertise.

Informations

Director: Ahmed Mazzah

http://msap-lab.fr

Bâtiment C4, Avenue Paul Langevin
Campus Cité Scientifique, Université de Lille
59655 VILLENEUVE D’ASCQ

Mots-clés

Flow chemistry, Mass spectrometry, Proteomics, Cultural heritage, Miniaturization, Chromatography, Separation techniques, Synthesis, Organic physico-chemistry

Localisation

  • Mass spectrometry
  • Proteomics
  • Post-translational modifications (phosphorylation, glycosylation ...)
  • Instrumental development
  • Analytical developments: biomolecules, biobased
  • Development of microreactors in organic synthesis
  • Flow chemistry
  • Chromatography
  • Separation techniques
  • Fine chemistry in multiscale microfluidic device
  • Synthesis of nanoparticles
  • Organic physico-chemistry
  • Photochemistry

Examples of projects:

  • Actinometric analysis of compounds
  • Multi-scale analysis of yeasts and their hydrolysates, from peptides to proteins
  • Study of the works of Amadeo MODIGLIANI (LaM Lille Métropole Musée d'Art Moderne)
  • Identification of biological macromolecules
  • Analysis of works of art
  • Organic & bioorganic analysis of cultural heritage samples
  • Proteomic, lipidomic, glycomic analysis
  • Development of microfluidic devices
  • Lipid analysis with identification of structures by fragmentation in CID or IRMPD
  • Top-Down analyzes with nanochromatographic coupling
  • Identification, quantification and analysis of proteins
  • Analysis of post-translational modifications (phosphorylation, glycosylation ...)
  • Enrichment in phospho or glycopeptides / proteins with the use of custom columns
  • Analysis of lipids such as triacylglycerols or metabolomics

We possess a wide range of equipment regrouped within the internal and external technological platforms comprising equipment for sample preparation, for proteomic analysis and by mass spectrometry, for data analysis. We also have:

  • Mass spectrometers
  • Nano-HPLC

See the detailed list of equipment.

Private
Roquette, Lesaffre, Mäder Group...

Academic
University of Louvain (Belgium), University of Quebec (Canada), University of Gent (Belgium), University of Hong Kong (Hong Kong)

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