Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases

EGENODIA | UMR 8199 - U 1283
Biology and health Research unit Precision health

The goal of our unit is to identify new genes involved in diabetes and obesity, and to better diagnose the forms of diabetes and obesity of genetic origin, thus allowing personalized medicine according to the genetic subtype. Our work also aims to better stratify the genetic and environmental risk factors, as well as the primary genetic causes, of metabolic diseases at different ages of life. We are developing translational concepts to allow individualized therapies for obese and diabetic patients. Different "multiomics" approaches are carried out using our unique genomics platform LIGAN-PM (high throughput DNA and RNA sequencing, genotyping and transcriptomic analysis using DNA chips, digital molecular counting via NanoString technology).

Informations

Director: Philippe Froguel

http://www.good.cnrs.fr/
https://twitter.com/UMR1283

1, place de Verdun
Faculté de Médecine - Pôle Recherche, Université de Lille
59045 LILLE

Mots-clés

Genetics, (Epi)genetics, Obesity, Diabetes, Cell biology, Personalized medicine, Metabolic diseases, Physiopathologies, Molecular mechanisms, Endocrinology

Localisation

  • Genetics of metabolic diseases
  • Prediction, prevention and therapy of diabetes and obesity
  • Personalized therapy for metabolic diseases
  • Genetics and epigenetics of diabetes and obesity
  • Molecular bases and modeling of diabetes and obesity
  • Preparation and management of BioBanque
  • High throughput sequencing (NGS) + analyzes (bioinformatics & biostatistics)

Examples of projects:

  • ERC Reg-Seq: Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing
  • PreciDiab National Center for Precision Diabetic Medicine
  • Preparation and extraction of DNA, RNA from blood or tissue, saliva and cell pellet
  • Genotyping
  • Expression analysis
  • NGS sequencing
  • Bioinformatics and statistical analysis

Biological materials

  • Cell lines: murine and human beta cell models
  • Murine models: Knock-out tissue specific, overexpression, physiological model for metabolic perturbations analysis ...
  • Biological collections: DNA from different patient cohorts

Private
Numerous collaborations with the pharmaceutical industry and biotechnology companies: Sanofi, Servier, Eli Lilly, Enterome, etc.
2 RHU in progress: iMAP with private partners ILTOO Pharma and IMMUNOTECH BECKMAN COULTER and PreciNASH with SANOFI

Academic
PARCC (Université de Paris), Université de Nice, ...
Imperial College London (UK), University of Jena (Germany), Lund University (Sweden), University of Oxford (UK), Harvard University (USA), Leiden University (Netherlands), Helmholtz Association (Germany), Wellcome Centre for Human Genetics (UK), Shriners Hospitals for Children (USA), ...

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