Lille In vivo Imaging and Functional Exploration

LIIFE
Biology and health Platform Precision health

Our platform brings together resources and expertise in in-vivo imaging in humans and rodents, and in behavioral analysis of rodents. We offer tools for the cross-sectional study of a wide range of pathologies, particularly in neurological and psychiatric diseases. We propose both harmonization of advanced MRI sequences between the Rodent and Human platforms, as well as signal analysis methods, allowing users to benefit from advanced techniques, such as brain connectivity analysis, morphometry, magnetic susceptibility quantification, automatic segmentation tools, as well as artificial intelligence techniques. We are open to academic and industrial collaborations.

Informations

Scientific director: Jean-Pierre Pruvo
Technical director: Renaud Lopes

https://ums-plbs.univ-lille.fr/les-plateformes-constitutives/imagerie-du-vivant-et-fonctions
https://twitter.com/ci2clab

1 place de Verdun
Faculté de médecine, Pôle recherche
59000 LILLE

Mots-clés

Imaging, Behavior, Functions, Neurology, Brain, Brain activity, MRI, Micro-MRI, Micro-PET-CT

Localisation

  • In-vivo imaging
  • Behavioral and functional analysis
  • MRI imaging
  • Morphological exploration of organs by MRI
  • Evaluation of rodent physiopathological models
  • Brain connectivity
  • Morphometry
  • Magnetic susceptibility
  • Artificial intelligence
  • Data processing and computer tools related to imaging

Examples of projects:

Rodent platform

  • Quantification of biological phenomena by relaxometry, diffusion and MR spectroscopy
  • Morphological exploration of organs by MRI
  • Data processing and development of IT tools related to preclinical medical imaging

Human platform

  • Highlighting the structural organization of the brain:

   - volume and surface analysis, morphometry
   - mapping of diffusion/tractography imaging
   - perfusion imaging

  • Extraction of functional organization:

   - task-specific activation
   - brain at rest: brain networks, functional connectome

  • Statistical analysis, data processing and development of computer tools (statistics, signal processing or artificial intelligence) related to imaging

We possess a wide range of equipment regrouped within the rodent and human platforms:

  • 7T MRI (Diffusion tensor, ASL and T1 perfusion, T1 and T2 relaxometry...)  
  • a small animal micro-PET-CT that offers the possibility to perform PET imaging coupled with CT in rodents using a fluorinated radiotracer (FDG, FDOPA)
  • behavioural and functional exploration platform, allowing the evaluation of rodent pathophysiological models for cognitive abilities, motor disorders, and anxiety/depression traits
  • 3T MRI dedicated to the research in the Lille University Hospital
  • 128 channel EGI's MR-compatible EEG Systems
  • ESys fMRI System with complex experimental paradigm in functional imaging
  • Cluster 176 CPU Cores 470 Gb RAM that supports the entire imaging data analysis computation in an optimal way

See the detailed list of equipment.

Private
CATI Paris, General Electric, Philips

Academic
Centre de recherche en automatique de Nancy (CRAN), CHU Amiens, CHU Bordeaux, Hôpital fondation Rotschild, CRMBM Marseille, NeuroSpin Paris

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