Laboratory of Cell Physiology

The scientific project of our laboratory encompasses fundamental aspects of ion channels’ biology with a particular focus on the consequences of their dysregulation during the development of prostate, pancreatic and colon cancers. Our experimental approaches include electrophysiology, imaging, biochemistry, molecular biology and flow cytometry techniques, validated in novel in vivo models. Our understanding of ion channels and some associated inflammasomes in pathological conditions allows us to develop biomarkers and innovative therapeutic approaches for a better management of "oncochannelopathies". Given the molecular complexity, tumor heterogeneity as well as resistance to anti-cancer therapies, we propose a strategy focused on ion channels and associated inflammasomes. This strategy has three components: (1) Identify a molecular "signature" that can be used for the development of a diagnostic/prognostic test for efficacy/toxicity to locoregional therapies in close collaboration with clinicians. (2) Develop the visualization and measurement of dynamic alterations of channels and inflammasomes during carcinogenesis. (3) Improve the current personalized medicine strategy against prostate, pancreatic and colorectal cancers.