Risk factors and molecular determinants of aging-related diseases

RID-AGE | U 1167
Biology and health Research unit Precision health

The main goal of our laboratory is to analyze, explore and understand the trends and determinants of major chronic diseases (cardiovascular and neurodegenerative) related to aging in order to propose new approaches for prevention and treatment, paving the way for personalized medicine and increased life expectancy without disability. Our laboratory is open to collaborations.

Informations

Director: Philippe Amouyel

https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/facteurs-de-risque-et-determinants-moleculaires-des-maladies-liees-au-vieillissement/

1 rue du professeur Calmette
Institut Pasteur de Lille
59019 LILLE

Mots-clés

Vieillissement, Maladies chroniques, Maladies cardiovasculaires, Maladies neurodégénératives, Maladie d'Alzheimer, Physiopathologie, Génomique, Bioinformatique, Données massives, Glycation

Localisation

  • Public Health
  • High-throughput genomics, bioinformatics, High Content Screening
  • Molecular aspects of aging pathologies
  • Inflammaging
  • Chronic diseases
  • Cardiovascular, cerebrovascular and metabolic diseases
  • Neurodegenerative diseases
  • Alzheimer's disease
  • Metabolism 
  • Glycation
  • Study of membrane proteins and their post-translational modifications
  • Analysis of molecular interactions
  • Prognostic biomarkers research
  • Approaches for prevention of chronic diseases

We possess state-of-the-art scientific instruments gathered within internal and external technological platforms:

  • Confocal microscope 
  • Electrophoresis systems Biorad Protean IEF, Protean II and GE Healthcare Ettan DaltSix
  • Powerlook 3 (UMAX) black and white scanner
  • Ettan DIGE fluorescence scanner (GE Healthcare)
  • Biorad SELDI-TOF PCS4000 mass spectrometer
  • Bio-Plex 2000 immunoanalysis system

Biological materials

  • Cell lines: HEK293
  • Primary cells: mesangial cells
  • Caenorhabditis elegans
  • Mouse models, zebrafish... (knock-out...) : RAGE-/- mice
  • Large DNA and plasma libraries hosted by the Biological Resource Center of the Pasteur Institute of Lille

Acadéemic
University of Paris, Sorbonne University, University of Bordeaux, INSB, University of Paris Saclay, CHU Bordeaux, Hopital Universitaire Pitie-Salpetriere - APHP, CHU Strasbourg, CHU de Toulouse, University of Strasbourg
University of London (United Kingdom), Harvard University (United States), Helmholtz Association (Germany), Erasmus University Rotterdam (Netherlands), Karolinska Institutet (Sweden), University College London (United Kingdom), University of California System (United States), Ghent University (Belgium), Boston University (United States), University of Oxford (United Kingdom), CIBER - Centro de Investigacion Biomedica en Red (Spain), University of Edinburgh (United Kingdom), University of Washington (United States), University of Cambridge (United Kingdom), University of Washington Seattle (United States)

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